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Dr. Nancy Cibotti-Granof (Medicine): A 46-year-old woman with end-stage renal disease was seen by a rheumatology consultant because of stiffness of her joints and skin.
The patient had been well except for mild asthma until 7 years earlier, when group A streptococcal pneumonia developed, complicated by septic shock, with acute respiratory distress syndrome; septic emboli to the lungs, brain, and kidney; renal failure requiring dialysis; flaccid quadriplegia; and coma. On the 25th day after initial admission to another hospital, she was transferred to this hospital while she was receiving mechanical ventilation.
As part of the evaluation during admission, computed tomography
Differential Diagnosis
Peripheral Neuropathy
Respiratory Failure
Granulomatous Pulmonary Disease
Congestive Heart Failure
Amyloidosis
Fibrosing Disorders
Beta2-Microglobulin Amyloidosis
Nephrogenic Systemic Fibrosis
Dr. Jonathan Kay's Diagnosis
Pathological Discussion
Discussion of Management
Pathological Discussion
Anatomical Diagnosis
Source Information
From the Department of Medicine, Division of Rheumatology, Allergy, and Immunology (J.K.), and the Departments of Nephrology (H.B.), Radiology (L.L.A.), and Pathology (A.F.K.), Massachusetts General Hospital; and the Departments of Medicine (J.K., H.B.), Radiology (L.L.A.), and Pathology (A.F.K.), Harvard Medical School.
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