FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 349:2468-2469 December 18, 2003 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Supplementary Material Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

To the Editor: The identification and sequencing of a novel coronavirus¹ associated with the recently described severe acute respiratory syndrome (SARS)² have permitted the development of antibody-based and genome-based tests for the infection.^3,4 Although antibody seroconversion provides reliable proof of infection, it is not suitable for early diagnosis. Techniques for genome detection have the potential to provide earlier diagnosis, but the sensitivity of genome-based tests of respiratory samples such as nasal and throat swabs is likely to be low in patients presenting early with fever alone, before the development of respiratory symptoms. We therefore investigated the potential of genome detection . . . [Full Text of this Article]

This article has been cited by other articles:

• Groner, A. (2008). Reply. Pereira A. Cryoprecipitate versus commercial fibrinogen concentrate in patients who occasionally require a therapeutic supply of fibrinogen: risk comparison in the case of an emerging transfusion-transmitted infection.. haematol 93: e24-e26 [Full Text]  
• Fujimoto, K., Chan, K.-H., Takeda, K., Lo, K.-F., Leung, R. H. K., Okamoto, T. (2008). Sensitive and Specific Enzyme-Linked Immunosorbent Assay Using Chemiluminescence for Detection of Severe Acute Respiratory Syndrome Viral Infection. J. Clin. Microbiol. 46: 302-310 [Abstract] [Full Text]  
• Cheng, V. C. C., Lau, S. K. P., Woo, P. C. Y., Yuen, K. Y. (2007). Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection. Clin. Microbiol. Rev. 20: 660-694 [Abstract] [Full Text]  
• Mahony, J. B., Richardson, S. (2005). Molecular Diagnosis of Severe Acute Respiratory Syndrome: The State of the Art. J. Mol. Diagn. 7: 551-559 [Abstract] [Full Text]  
• Kang, X., Xu, Y., Wu, X., Liang, Y., Wang, C., Guo, J., Wang, Y., Chen, M., Wu, D., Wang, Y., Bi, S., Qiu, Y., Lu, P., Cheng, J., Xiao, B., Hu, L., Gao, X., Liu, J., Wang, Y., Song, Y., Zhang, L., Suo, F., Chen, T., Huang, Z., Zhao, Y., Lu, H., Pan, C., Tang, H. (2005). Proteomic Fingerprints for Potential Application to Early Diagnosis of Severe Acute Respiratory Syndrome. Clin. Chem. 51: 56-64 [Abstract] [Full Text]  
• Hui, D. S.C., Sung, J. J.Y. (2004). Treatment of Severe Acute Respiratory Syndrome. Chest 126: 670-674 [Full Text]  
• Parashar, U. D, Anderson, L. J (2004). Severe acute respiratory syndrome: review and lessons of the 2003 outbreak. Int J Epidemiol 33: 628-634 [Full Text]  
• Wang, H., Mao, Y., Ju, L., Zhang, J., Liu, Z., Zhou, X., Li, Q., Wang, Y., Kim, S., Zhang, L. (2004). Detection and Monitoring of SARS Coronavirus in the Plasma and Peripheral Blood Lymphocytes of Patients with Severe Acute Respiratory Syndrome. Clin. Chem. 50: 1237-1240 [Full Text]  
• Hui, D S C, Chan, M C H, Wu, A K, Ng, P C (2004). Severe acute respiratory syndrome (SARS): epidemiology and clinical features. Postgrad. Med. J. 80: 373-381 [Abstract] [Full Text]  
• Poon, L. L.M., Leung, C. S.W., Tashiro, M., Chan, K. H., Wong, B. W.Y., Yuen, K. Y., Guan, Y., Peiris, J. S.M. (2004). Rapid Detection of the Severe Acute Respiratory Syndrome (SARS) Coronavirus by a Loop-Mediated Isothermal Amplification Assay. Clin. Chem. 50: 1050-1052 [Full Text]  
• Bruner, J. M. (2004). Six Cities Revisited. NEJM 350: 1577-1577 [Full Text]  
• Yu, A. C.-H., Lau, L.-T., Fung, Y.-W. W. (2004). Boosting the Sensitivity of Real-Time Polymerase-Chain-Reaction Testing for SARS. NEJM 350: 1577-1579 [Full Text]