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Correspondence
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Volume 349:709 August 14, 2003 Number 7
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A Novel Coronavirus and SARS

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 by Ksiazek, T. G.
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To the Editor: Ksiazek et al. (May 15 issue)1 report that there is antibody cross-reactivity between serum from a patient with severe acute respiratory distress syndrome (SARS) and antibodies that are reactive with group I coronaviruses. This finding raises the possibility of using existing vaccines against these heterologous coronaviruses for protection against SARS. Unfortunately, the study did not show any virus-neutralization activity. Nevertheless, the close similarity between the SARS open reading frame 1b and other human and animal coronaviruses lends support to the idea of using heterologous coronaviral strains, which are harmless to humans, as vaccines. There are several historical . . . [Full Text of this Article]




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