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Previous Volume 357:1759-1761 October 25, 2007 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The normalization of glucose levels plays an important role in protecting patients with diabetes from complications such as myocardial infarction and stroke. To accomplish this goal, most patients with type 2 diabetes will ultimately require treatment with insulin, since oral antidiabetic drugs become insufficient as insulin production declines. Many diabetologists recommend that insulin therapy be initiated if a patient has a glycated hemoglobin level of more than 7% after having received the maximal dose of two oral agents for more than a few months.¹

The question of how to initiate insulin therapy in patients with type 2 diabetes has become . . . [Full Text of this Article]

Source Information

This article (10.1056/NEJMe078196) was published at www.nejm.org on September 21, 2007.

Drs. McMahon and Dluhy are editors at the Journal.

Related Letters:

Addition of Insulin to Oral Therapy in Type 2 Diabetes
Dadelen S., Ilag L. L., Martin S., Jacober S. J., Holman R. R., Farmer A. J., Davies M. J., McMahon G. T., Dluhy R. G.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:1197-1198, Mar 13, 2008. Correspondence

This article has been cited by other articles:

• Esposito, K., Ciotola, M., Maiorino, M. I., Gualdiero, R., Schisano, B., Ceriello, A., Beneduce, F., Feola, G., Giugliano, D. (2008). Addition of Neutral Protamine Lispro Insulin or Insulin Glargine to Oral Type 2 Diabetes Regimens for Patients with Suboptimal Glycemic Control: A Randomized Trial. ANN INTERN MED 149: 531-539 [Abstract] [Full Text]  
• Dagdelen, S., Ilag, L. L., Martin, S., Jacober, S. J., Holman, R. R., Farmer, A. J., Davies, M. J., McMahon, G. T., Dluhy, R. G. (2008). Addition of insulin to oral therapy in type 2 diabetes.. NEJM 358: 1197-1198 [Full Text]  
• Riddle, M. C. (2008). Starting and Advancing Insulin for Type 2 Diabetes: Algorithms and Individualized Methods Are Both Necessary. J. Clin. Endocrinol. Metab. 93: 372-374 [Full Text]