Patients with human immunodeficiency virus (HIV) infection oftenhave a reduced mass of skeletal muscle and bone and a maldistributionof body fat. Loss of muscle mass, strength, and function areintegral to the AIDS wasting syndrome and are associated withresistance to the anabolic effects of growth hormone. Administrationof growth hormone in relatively high daily doses for 12 weeksimproves muscle mass, strength, and function but leads to excesssalt and water retention, the carpal tunnel syndrome, glucoseintolerance, and insulin resistance, whereas the use of somewhatlower doses or an alternate-day regimen elicits similar beneficialeffects with . . . [Full Text of this Article]
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From the Research Service, Veterans Affairs Medical Center, Washington, DC.
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