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Previous Volume 358:47-54 January 3, 2008 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presented. The article ends with the author's clinical recommendations.

A 23-year-old woman with known polycystic ovary syndrome visits her family physician. She has taken oral contraceptive pills in the past but did not tolerate them and is not currently receiving any treatment. She has three or four menstrual . . . [Full Text of this Article]

The Clinical Problem

Pathophysiology and Effect of Therapy

Clinical Evidence

Clinical Use

Adverse Effects

Areas of Uncertainty

Guidelines

Recommendations

Source Information

From the Departments of Internal Medicine, Obstetrics and Gynecology, and Pharmacology and Toxicology, Virginia Commonwealth University, Richmond.

Address reprint requests to Dr. Nestler at the Division of Endocrinology and Metabolism, Medical College of Virginia, PO Box 980111, Richmond, VA 23298-0111, or at jnestler@mcvh-vcu.edu.

Related Letters:

Metformin in Polycystic Ovary Syndrome
Raskauskas T. A., Fisken R. A., Targher G., Lippi G., Moghetti P., Mascitelli L., Pezzetta F., Goldstein M. R., Nestler J. E.
Extract | Full Text | PDF  
N Engl J Med 2008; 358:1866-1868, Apr 24, 2008. Correspondence

This article has been cited by other articles:

• Jensterle, M., Sebestjen, M., Janez, A., Prezelj, J., Kocjan, T., Keber, I., Pfeifer, M. (2008). Improvement of endothelial function with metformin and rosiglitazone treatment in women with polycystic ovary syndrome. Eur J Endocrinol 159: 399-406 [Abstract] [Full Text]  
• Pistrosch, F., Herbrig, K., Parmentier, S., Gross, P. (2008). New onset of alopecia in a young woman with end-stage renal disease. NDT Plus 1: 162-163 [Full Text]  
• Baillargeon, J.-P., Nestler, J. E., Ostlund, R. E., Apridonidze, T., Diamanti-Kandarakis, E. (2008). Greek hyperinsulinemic women, with or without polycystic ovary syndrome, display altered inositols metabolism. Hum Reprod 23: 1439-1446 [Abstract] [Full Text]  
• Raskauskas, T. A., Fisken, R. A., Targher, G., Lippi, G., Moghetti, P., Mascitelli, L., Pezzetta, F., Goldstein, M. R., Nestler, J. E. (2008). Metformin in Polycystic Ovary Syndrome. NEJM 358: 1866-1868 [Full Text]