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Case Records of the Massachusetts General Hospital
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Volume 358:2161-2168 May 15, 2008 Number 20
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Case 15-2008 — A 55-Year-Old Man with an Elevated Prostate-Specific Antigen Level and Early-Stage Prostate Cancer
Michael J. Barry, M.D., Donald S. Kaufman, M.D., and Chin-Lee Wu, M.D., Ph.D.

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Presentation of Case

Dr. Donald S. Kaufman: A 55-year-old man was referred to this hospital for management of prostate cancer. He had been well until approximately 1 year earlier, when he noted the progressively decreasing force of his urinary stream, increasing urinary urgency, and nocturia up to four times per night. At that time, he had noted decreased libido for several months, but his erections were adequate for intercourse. His primary care physician obtained a measurement of serum prostate-specific antigen (PSA), which was 6.6 ng per milliliter. The patient was referred to a local urologist. On examination, the abdomen and external genitalia were . . . [Full Text of this Article]

Pathological Discussion

Discussion of Management

Important Features of the Case

Determining the Prognosis

            Characteristics of the Patient

            Characteristics of the Cancer

Models of Survival in the PSA Era

The Case for Conservative Management

Summary of Management

Anatomical Diagnosis


Source Information

From the Department of Medicine (M.J.B.), the Hematology–Oncology Unit (D.S.K.), and the Department of Pathology (C.-L.W.), Massachusetts General Hospital; and the Departments of Medicine (M.J.B., D.S.K.) and Pathology (C.-L.W.), Harvard Medical School.




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