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Dr. Donald S. Kaufman: A 55-year-old man was referred to this hospital for management of prostate cancer. He had been well until approximately 1 year earlier, when he noted the progressively decreasing force of his urinary stream, increasing urinary urgency, and nocturia up to four times per night. At that time, he had noted decreased libido for several months, but his erections were adequate for intercourse. His primary care physician obtained a measurement of serum prostate-specific antigen (PSA), which was 6.6 ng per milliliter. The patient was referred to a local urologist. On examination, the abdomen and external genitalia were
Pathological Discussion
Discussion of Management
Important Features of the Case
Determining the Prognosis
Characteristics of the Patient
Characteristics of the Cancer
Models of Survival in the PSA Era
The Case for Conservative Management
Summary of Management
Anatomical Diagnosis
Source Information
From the Department of Medicine (M.J.B.), the Hematology–Oncology Unit (D.S.K.), and the Department of Pathology (C.-L.W.), Massachusetts General Hospital; and the Departments of Medicine (M.J.B., D.S.K.) and Pathology (C.-L.W.), Harvard Medical School.
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