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Volume 358:2413-2414 May 29, 2008 Number 22
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Acute Lower Respiratory Tract Infection

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by Mizgerd, J. P.
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To the Editor: In his review of inflammatory responses in infected lungs, Mizgerd (Feb. 14 issue)1 notes that animal models of influenza A virus pneumonia indicate that neither neutrophil leukocytes nor cytokine signaling seems to be important in the case of the highly pathogenic influenza virus infections that cause global pandemics. However, this influenza virus directly inhibits pulmonary epithelial sodium transport, which removes water from the alveolar space by osmosis: Viral hemagglutinin binds to receptors on respiratory epithelial cells, inhibiting epithelial sodium-channel–mediated clearance of pulmonary fluid through a pathway involving phospholipase and protein kinase C.2,3 Reduced epithelial sodium transport also . . . [Full Text of this Article]



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