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Previous Volume 358:2698-2703 June 19, 2008 Number 25 Next

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SUMMARY

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

Source Information

From the Fred Hutchinson Cancer Research Center (N.N.H., H.W., J.C., D.W.H., J.Z.R., R.R., C.Y.) and the University of Washington (J.A.T., C.Y.) — both in Seattle; and the Ludwig Institute for Cancer Research (New York Branch), Memorial Sloan-Kettering Cancer Center, New York (A.J., S.G.).

Address reprint requests to Dr. Yee at the Fred Hutchinson Cancer Research Center, Room D3-100, 1100 Fairview Ave. N., Seattle, WA 98109, or at cyee{at}fhcrc.org.

Full Text of this Article

Related Letters:

Cancer Immunotherapy
Rosenberg S. A., Dudley M. E., Restifo N. P., Prestwich R., Vile R., Melcher A., Weiner L. M.
Extract | Full Text | PDF  
N Engl J Med 2008; 359:1072-1073, Sep 4, 2008. Correspondence

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