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Previous Volume 358:2735-2736 June 19, 2008 Number 25 Next

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose--1,3-Galactose

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To the Editor: Chung and colleagues (March 13 issue)¹ found IgE antibodies to galactose--1,3-galactose in pretreatment serum samples from 17 of 25 patients who had hypersensitivity reactions to cetuximab, whereas IgE antibodies were found in only 1 of 51 patients who did not have a hypersensitivity reaction. If, as suggested, the presence of such antibodies in pretreatment samples is predictive of anaphylaxis, pretreatment testing would help in minimizing the risk of anaphylaxis associated with cetuximab. It would be important to know whether skin testing was done in the study patients, and if so, whether the results were concordant with . . . [Full Text of this Article]

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