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Volume 358:2736-2738 June 19, 2008 Number 25
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Vasopressin in Septic Shock

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by Parrillo, J. E.
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by Russell, J. A.
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To the Editor: The results of the Vasopressin and Septic Shock Trial (VASST), reported by Russell et al. (Feb. 28 issue),1 do not fully support the conclusion that "low-dose vasopressin did not reduce mortality." The secondary hypothesis that "the beneficial effects of vasopressin would be more pronounced . . . in the subgroup of patients with more severe (as opposed to less severe) septic shock" was clearly refuted. However, in the vasopressin-treated patients with less severe shock, the 25.8% relative reduction in 28-day mortality is both striking and significant. Since the subgroup stratification was done prospectively, this result appears to be more . . . [Full Text of this Article]



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