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Previous Volume 359:529-533 July 31, 2008 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Brown, B. G. Related Article by Drazen, J. M. Related Article by Kastelein, J. J.P. PubMed Citation

To the Editor: In the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) study by Kastelein et al. (April 3 issue),¹ the addition of ezetimibe to simvastatin boosted the decrease in levels of low-density lipoprotein (LDL) cholesterol from 39.1% to 55.6%. However, the greater decrease in LDL cholesterol in the combined-therapy group did not affect progression of the carotid intima–media thickness. Some observers have suggested that the results of the ENHANCE study force us to question the basic lipid hypothesis of atherogenesis.

No single study can possibly counter the extensive body of evidence that lowering of plasma cholesterol levels . . . [Full Text of this Article]

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