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Previous Volume 359:535 July 31, 2008 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Watson-Jones et al. (April 10 issue)¹ report that the suppression of herpes simplex virus type 2 (HSV-2) does not decrease the incidence of human immunodeficiency virus (HIV) infection in female workers at recreational facilities in northwestern Tanzania. However, this finding is disputable, since treatment with 400 mg of acyclovir twice daily did not suppress the incidence of HSV-2 infection. Any conclusion regarding the preventive effect of acyclovir should be based on the analysis of patients in whom the drug was detected, since the study is confounded because a majority of patients in the acyclovir group tested negative . . . [Full Text of this Article]

This article has been cited by other articles:

• McMahon, M. A., Siliciano, J. D., Lai, J., Liu, J. O., Stivers, J. T., Siliciano, R. F., Kohli, R. M. (2008). The Antiherpetic Drug Acyclovir Inhibits HIV Replication and Selects the V75I Reverse Transcriptase Multidrug Resistance Mutation. J. Biol. Chem. 283: 31289-31293 [Abstract] [Full Text]