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Previous Volume 359:760-761 August 14, 2008 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Zethelius et al. (May 15 issue)¹ suggest that the combination of multiple biomarkers with established risk factors results in an improved assessment of cardiovascular risk among elderly men. Unfortunately, they did not validate their findings in an independent cohort of patients.² Thus, a possibly spurious association they found in a highly selected subgroup may be erroneously generalized, particularly to women and to other age and ethnic groups. Why should we spend about 35 ($55) per patient to optimize our prognostic evaluation without having any proven effect on individual risk reduction? In contrast, simple and cheap risk scores . . . [Full Text of this Article]

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