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Volume 359:869-870 August 21, 2008 Number 8
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Sublingual Immunotherapy

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 by Frew, A. J.
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To the Editor: In his discussion of allergic rhinitis and the clinical use of sublingual immunotherapy, Frew (May 22 issue)1 reports that the adverse effects of such therapy have been limited mainly to the oral cavity, with only a few cases of anaphylaxis reported. To our knowledge, the studies whose results have been published so far did not look into the incidence of eosinophilic esophagitis with sublingual immunotherapy. Eosinophilic esophagitis is an emerging worldwide disease of unknown cause that mimics gastroesophageal reflux disease and can lead to esophageal narrowing and stricture.2 The majority of patients with the condition have evidence . . . [Full Text of this Article]




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