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reported. Clinical Follow-up After randomization, the first-day visit included a gynecologic examination and the taking of a medical history with collection of cervical samples for Papanicolaou testing (ThinPrep, Cytyc) and anogenital swabs (of the labial, vulvar, perineal, perianal, endocervical, and
N Engl J Med 356:1915, May 10, 2007 Original Article
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Whitcomb DC
compromise. 15 Pancreatic-Fluid Collections, Pseudocysts, and Necrosis Up to 57 percent of patients who are hospitalized with acute pancreatitis will have fluid collections, with 39 percent having two areas involved and 33 percent having three or more. 32 Fluid collections are initially ill defined, 21
N Engl J Med 354:2142, May 18, 2006 Clinical Practice
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Corneli HM, Zorc JJ, Majahan P, Shaw KN, Holubkov R, Reeves SD, Ruddy RM, Malik B, Nelson KA, Bregstein JS, Brown KM, Denenberg MN, Lillis KA, Cimpello LB, Tsung JW, Borgialli DA, Baskin MN, Teshome G, Goldstein MA, Monroe D, Dean JM, Kuppermann N
data collection to audit all study records. Before enrollment, study clinicians confirmed clinical bronchiolitis and determined the duration of symptoms and the RDAI score. Research assistants or clinicians obtained the medical history from parents or guardians on a standardized data-collection form
N Engl J Med 357:331, July 26, 2007 Original Article
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Tu JV, Willison DJ, Silver FL, Fang J, Richards JA, Laupacis A, Kapral MK
ethics boards or data holders may interpret the laws very conservatively, virtually mandating that informed consent be obtained before any data are collected. 6 13 Ideally, a very high percentage of patients (e.g., more than 95 percent) would be approached and would agree to participate in a clinical registry
N Engl J Med 350:1414, April 1, 2004 Special Article
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Christakis NA, Fowler JH
(see the Supplementary Appendix, available with the full text of this article at www.nejm.org). Validated measures of cigarette consumption were collected at each time point. 14 15 Network Ascertainment For our study, we used the offspring cohort as the source of 5124 subjects (known as “egos” in
N Engl J Med 358:2249, May 22, 2008 Special Article
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Schmidt PJ
million units of blood were collected nationwide. Three organizations collect and deliver blood in the United States. All three are not-for-profit organizations, and no blood donors are paid. The American Red Cross operates nationwide under a single federal license. It collects almost half the nation's
N Engl J Med 346:617, February 21, 2002 Sounding Board
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D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML
Hopkins Hospital. Written, informed consent was obtained from all patients. Data Collection Specimens were collected from case patients before therapy and from control patients at enrollment. Oral-mucosal specimens were collected with the use of a saline oral rinse and 5 to 10 strokes of a cytology brush
N Engl J Med 356:1944, May 10, 2007 Original Article
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O'Doherty C, Kantarci O, Vandenbroeck K
SNPs in IL7RA in two independent case-control collections from Olmsted County, Minnesota, and Belfast, Northern Ireland, neither of which, to our knowledge, has previously been tested for IL7RA ( Table 1). Clinical and demographic data for both collections have been described elsewhere. 5 Analysis of
N Engl J Med 358:753, February 14, 2008 Correspondence
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Quackenbush J
disputed, 33 a nationwide clinical trial is under way in the Netherlands in which gene-expression profiles for these 70 classifier genes are being collected from all newly identified consenting patients with breast cancer and used as an adjunct to classic clinical staging. This is an important step in
N Engl J Med 354:2463, June 8, 2006 Review Article
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Choudhry S, Brennan TA
Collective bargaining has caught the imagination of physicians across the United States. Although physicians' unions have existed since the 1970s, union members have always constituted an extremely small percentage of practicing physicians. 1 However, physicians are turning to unions to increase their
N Engl J Med 345:1141, October 11, 2001 Legal Issues in Medicine
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Lomas DC
No organ has a more immediate and vital connection to human life than the heart. Although we have learned to recognize the brain as the seat of our emotions, cultural symbols — from Valentine's Day cards to images of the Sacred Heart — persist in connecting the heart with the human passions of
N Engl J Med 358:756, February 14, 2008 Book Review
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Yacht AC
engage in collective bargaining. This ruling overturned a controversial 1976 decision by the NLRB that blocked the house staff at Cedars-Sinai Medical Center in Los Angeles from organizing a union. 1 After the 1976 ruling, several private hospitals that had previously recognized collective-bargaining
N Engl J Med 342:429, February 10, 2000 Sounding Board
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Adelman SH, Beauchamp ML, Yaes RJ, Whyte JJ, Yacht AC, Cohen JJ
To the Editor: Both Dr. Yacht and Dr. Cohen (Feb. 10 issue) 1 2 present excellent arguments for and against collective bargaining by residents, respectively. Dr. Cohen asks residents first to try other means of being heard, not unions. Physicians for Responsible Negotiation, a national labor organization
N Engl J Med 342:1919, June 22, 2000 Correspondence
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Iwamoto M, Jernigan DB, Guasch A, Trepka MJ, Blackmore CG, Hellinger WC, Pham SM, Zaki S, Lanciotti RS, Lance-Parker SE, DiazGranados CA, Winquist AG, Perlino CA, Wiersma S, Hillyer KL, Goodman JL, Marfin AA, Chamberland ME, Petersen LR
of Blood Donors We reviewed the blood-transfusion histories of the organ donor and the transplant recipients and notified the implicated blood-collection agencies. Donations associated with blood components given to the organ donor, other blood components manufactured from these donations (co-components
N Engl J Med 348:2196, May 29, 2003 Original Article
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Stramer SL, Fang CT, Foster GA, Wagner AG, Brodsky JP, Dodd RY
(Abbott Laboratories) were selected for use in confirmation and follow-up studies. Sample Collection and Laboratory Testing Plasma samples to be screened for West Nile virus RNA were obtained from the collected Plasma-Preparation Tubes (Becton Dickinson) used for routine screening for human immunodeficiency
N Engl J Med 353:451, August 4, 2005 Original Article
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Annas GJ
seems at least as strange to try to sell a baby's placental blood (also termed umbilical-cord blood) to the newborn's mother by charging her for collecting and storing it. What makes this waste product of childbirth suddenly valuable to both parents and the public? The answer is that placental blood
N Engl J Med 340:1521, May 13, 1999 Legal Issues in Medicine
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Pauk J, Huang ML, Brodie SJ, Wald A, Koelle DM, Schacker T, Celum C, Selke S, Corey L
, and other human herpesviruses, and the men were enrolled in protocols that evaluated patterns of viral shedding from mucosal sites. One cohort collected daily samples at home by rubbing separate swabs over the buccal and lingual surfaces, anal mucosa, and urethra. 22 The second cohort, enrolled in
N Engl J Med 343:1369, November 9, 2000 Original Article
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containing at least 10 6, 10 5, and 10 5.8 median tissue-culture infective doses (TCID 50) to poliovirus types 1, 2, and 3, respectively. Sample Collection Serologic specimens were taken from infants immediately before administration of the first vaccine dose and approximately 4 weeks after the last
N Engl J Med 356:1536, April 12, 2007 Original Article
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Kush RD, Helton E, Rockhold FW, Hardison CD
system is implemented, however, it is frequently customized for the users. This means that even record systems developed by the same vendor could collect the same information in different ways for different institutions. For example, the relationship between an adverse event and a particular therapy
N Engl J Med 358:1738, April 17, 2008 Sounding Board
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misclassification of ventilator-associated pneumonia. 8 9 Bronchoscopy with quantitative culture of bronchoalveolar-lavage fluid or of specimens collected through a protected brush catheter may yield superior diagnostic information. However, in the absence of a reference standard for the diagnosis of
N Engl J Med 355:2619, December 21, 2006 Original Article
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