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Laffey JG, Kavanagh BP
in the regulation of the cerebral circulation. Intracranial Hypertension The cranial cavity has a fixed volume, and when the mass of any of its contents increases (as it may, for example, in patients with cerebral edema, hematoma after a head injury, or a brain tumor), a critical elevation of intracranial
N Engl J Med 347:43, July 4, 2002 Review Article
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Gulati S, Gulati K, Sugiyama T, Tanaka H, Taguchi T, Cooper MS, Stewart PM, Leonard MB, Zemel BS, Stallings VA
glucocorticoids does not appear to be associated with deficits in bone mineral content in children with the nephrotic syndrome — results that differ from ours. 2 An important observation was a lower bone mineral content at the spine after correction for the body-mass index. The earliest changes of
N Engl J Med 351:2655, December 16, 2004 Correspondence
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Adrogue HJ, Madias NE
systolic blood pressure by an average of 2.0 mm Hg and diastolic blood pressure by an average of 1.0 mm Hg in normotensive subjects. 14 Potassium Content of Sodium-Rich Diets As compared with diets based on natural foods, diets based on processed foods are high in sodium and low in potassium. 3 10 For
N Engl J Med 356:1966, May 10, 2007 Review Article
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Leonard MB, Feldman HI, Shults J, Zemel BS, Foster BJ, Stallings VA
effects of glucocorticoids on the growing skeleton. We determined the effects of long-term therapy with high-dose glucocorticoids on the bone mineral content of the lumbar spine and whole body relative to bone size and body size in children and adolescents. Methods Study Subjects The study subjects were
N Engl J Med 351:868, August 26, 2004 Original Article
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Delves PJ, Roitt IM
bacteriophages, each bearing a different antibody of a single specificity on its surface and containing the genes for that antibody. 115 When the contents of this library are poured onto antigen-coated plastic dishes, phages bearing the relevant antibody will bind to the antigen, and those that do not
N Engl J Med 343:108, July 13, 2000 Review Article
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Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K
subjects were interviewed by the research dietitian at the Frederic C. Bartter General Clinical Research Center and instructed not to change the calorie content of their diet or their level of physical activity. The subjects were given placebo pills, and compliance was assessed by means of a pill count on follow
N Engl J Med 355:2297, November 30, 2006 Original Article
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Dember LM, Hawkins PN, Hazenberg BPC, Gorevic PD, Merlini G, Butrimiene I, Livneh A, Lesnyak O, Puechal X, Lachmann HJ, Obici L, Balshaw R, Garceau D, Hauck W, Skinner M
taken. At baseline and at the 12- and 24-month visits, abdominal fat was collected by aspiration for Congo red staining and quantification of amyloid content by an enzyme-linked immunosorbent assay with murine monoclonal antibodies to SAA. 17 Staining of abdominal fat and quantification of amyloid were performed
N Engl J Med 356:2349, June 7, 2007 Original Article
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Cuchel M, Bloedon LT, Szapary PO, Kolansky DM, Wolfe ML, Sarkis A, Millar JS, Ikewaki K, Siegelman ES, Gregg RE, Rader DJ
after drug withdrawal, with the use of chemical-shift MRI techniques that have been shown to evaluate fat content of the liver accurately. 15 16 All quantitative MRI measurements of hepatic fat content were performed by a single radiologist, who was unaware of the patients' clinical status and liver-function
N Engl J Med 356:148, January 11, 2007 Original Article
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Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI
risk. In this regard, studies measuring triglyceride content of muscle-biopsy specimens 6 or intramyocellular lipid content by means of proton ( 1H) magnetic resonance spectroscopy 7 8 9 indicate a strong relation between intramuscular lipid content and insulin resistance in skeletal muscle. Studies have
N Engl J Med 350:664, February 12, 2004 Original Article
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Chandalia M, Garg A, Lutjohann D, von Bergmann K, Grundy SM, Brinkley LJ
calculated by means of a software program based on the Department of Agriculture Handbook Series 8 (Nutriplanner, Practocare, San Diego, Calif.). 15 The content of total as well as soluble and insoluble dietary fiber was estimated according to the data provided in the CRC Handbook of Dietary Fiber in Human
N Engl J Med 342:1392, May 11, 2000 Original Article
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Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S, Gottwald MD, O'Neil N, Neuhaus JM, Segal MR, Lowenstein DH
Drug Treatment and Randomization Coded study kits contained two 2.5-ml colored-glass syringes. The syringes in a single study kit had identical contents: a 1.0-ml solution of either 5 mg of diazepam (Schein, Florham Park, N.J.; and Elkins-Sinn, Cherry Hill, N.J.) or 2 mg of lorazepam (Ativan, Wyeth
N Engl J Med 345:631, August 30, 2001 Original Article
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Kulkarni N, Pierse N, Rushton L, Grigg J
occupational settings. 7 In this study, we sought to determine the association between the carbon content of airway macrophages and lung function in a group of healthy children and the association between carbon content and variables that may affect individual exposure — such as exercise, 8 body-mass index
N Engl J Med 355:21, July 6, 2006 Original Article
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Kornfeld H, Mark EJ
A contrast-enhanced CT scan ( Figure 2) shows a smooth, sharply demarcated, round mass in the right lower lobe with peripheral enhancement. The contents of the mass are of low attenuation, which is characteristic of fluid. The mass abuts the chest wall without invading it. A smaller, irregular mass
N Engl J Med 341:974, September 23, 1999 Case Records of the Massachusetts General Hospital
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Marik PE
Aspiration is defined as the inhalation of oropharyngeal or gastric contents into the larynx and lower respiratory tract. 1 2 Several pulmonary syndromes may occur after aspiration, depending on the amount and nature of the aspirated material, the frequency of aspiration, and the host's response to
N Engl J Med 344:665, March 1, 2001 Review Article
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Camilleri M
proximal stomach serves as the reservoir of food, and the distal stomach as the grinder. 11 The physical nature, particle size, and fat and caloric content of food determine its emptying rate ( Figure 1). Non-nutrient liquids empty rapidly; the rate is fastest when there is a large volume. If there are
N Engl J Med 356:820, February 22, 2007 Clinical Practice
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Curfman GD, Morrissey S, Drazen JM
In the issue of April 26, 2001, we published a study by Jon Sudbø et al. 1 Figures 3B and 3C of that article, which purport to represent two different patients and stages of oral epithelial dysplasia, are in fact different magnifications of the same photomicrograph. Because the results of another
N Engl J Med 354:638, February 9, 2006 Editorial
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Meyer TW, Hostetter TH
renal disease undergo hemodialysis three times per week. The dialysis prescription is adjusted to remove about two thirds of the total-body urea content during each treatment ( Figure 1). This standard was adopted after clinical trials showed that to a point, patient outcomes improve with increasing
N Engl J Med 357:1316, September 27, 2007 Review Article
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Mangione-Smith R, DeCristofaro AH, Setodji CM, Keesey J, Klein DJ, Adams JL, Schuster MA, McGlynn EA
validity score of 7 or higher were included in the study. Previous work has shown this method of selecting indicators to be reliable and to have content, construct, and predictive validity in other applications. 15 16 17 The criteria for selecting the clinical areas, literature reviews, procedures followed
N Engl J Med 357:1515, October 11, 2007 Special Article
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Sudbo J, Kildal W, Risberg B, Koppang HS, Danielsen HE, Reith A
aberration of DNA content (ploidy) in carcinogenesis. 25 Three previous studies of the prognostic value of DNA quantitation in premalignant oral lesions included fewer than 25 patients with at least five years of follow-up. 26 27 28 In this report we describe the prognostic value of the DNA content in dysplastic
N Engl J Med 344:1270, April 26, 2001 Original Article
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Buffon A, Biasucci LM, Liuzzo G, D'Onofrio G, Crea F, Maseri A
patients with unstable angina, but not in those with stable angina or in controls. Activation was detected by measuring the neutrophil myeloperoxidase content, which is an index of more advanced inflammatory activation than that identified by measuring CD11b and CD18 expression. 17 18 We ascertained whether
N Engl J Med 347:5, July 4, 2002 Original Article
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