…-event curves are presented. The groups were compared in terms of the incidence of adverse effects with the use of chi-square tests. Because of the early release of the efficacy results, data on adverse events are provisional; the validation process is ongoing. Here, we emphasize the adverse effects for which…

…data over individual anecdotes and getting it right over getting it first, representatives of the world of medical science often felt pressure to release early clinical research prematurely to the public. And whereas journalists traditionally emphasized the use of multiple sources for new information and…

…during the past year, the Journal has released articles early by posting them on our site on the World Wide Web ( http://www.nejm.org). The decision to release an article early is made together with the authors and in accordance with our policy that permits early release when a report may have immediate implications…

…cutoff values used to define a positive test (ranging from 50 to 150 μg per liter) and in the timing of blood sampling. Because of the protein's early release and rapid clearance, the diagnostic accuracy of myoglobin levels is highly time dependent. In a prospective study involving 309 patients, de Winter…

…patients in an inpatient setting may not apply to patients after release from a chest-pain evaluation unit, 8 13 when some patients may rapidly resume cocaine use. For that reason, we believed it imperative to document the safety of early release in a prospective, “real-world” setting. The purpose of the…

…readers the importance of signing up (at www.nejm.org/alerts) to receive our electronic table of contents and e-mail alerts of all postings of early-release articles on the Web. This service is provided at no charge. Our strength derives from how we evaluate what we publish, and that process can be lengthy…

…the use of a ramp function. 19 An immediate change was defined as one occurring within three 4-month intervals (i.e., within 1 year) after the early release of the study's findings on the Journal Web site on July 19, 1999, 44 days ahead of its publication in print. 2 To assess delayed effects, we used…

…was also a higher rate of release of cardiac markers early after randomization in the PCI group that did not meet the trial criteria for myocardial infarction. The clinical consequences of reinfarction in this circumstance remain to be investigated. The mechanisms of early and late myocardial damage…